I cannot reproduce it here, I'm running MSFS 2024 right now, in flight, for about 30 minutes, no issues.
It seems related to .NET in some way, which GSX doesn't use, except for checking the license (using the SORACO library, which is the only .NET related part of the code ) but, the issue is, we are not constantly checking the license for products: only once at start and never again for the whole session.
Try enabling Windows 8 Compatibility mode for the Couatl64_MSFS2024.exe, it shouldn't be required, but it might be in some cases.