Yes, but everytime I have flown there never once have I taken off 4R and seen a/c landing on the 8's or vice versa.
Since FSX always gives precedence to runways with an ILS approach, you will not see landings on 8R or 26's. The only other runway that might be active together with 4R would be 8L.
But, you should really use the default AFCAD that comes with the current version. Because, that version doesn't have any approaches inside, it uses the default ones. But, if you modify the file, and use an AFCAD editor that sets the "DeleteAllApproaches=true" parameter when saving the AFCAD back, you will LOSE all the Approaches, because that command will make the default ones to be ignored, and with no approaches in the PHNL AFCAD, there will be an approaches at all so, ATC will just use the first available runway in the list, which is 4R.
You can easily check if your approaches are correct using the default GPS. If they are there, it means everything's fine.